2-Chloro-5,7-difluoroquinoline

Base Information

Chemical Name:2-Chloro-5,7-difluoroquinoline
CAS No.:1188002-20-1
Molecular Formula:C₉H₄ClF₂N
Molecular Weight:199.587
Hs Code.:
European Community (EC) Number:839-673-8
DSSTox Substance ID:DTXSID00700078
Nikkaji Number:J2.742.375B
Wikidata:Q82631260
Mol file:1188002-20-1.mol

Synonyms:2-CHLORO-5,7-DIFLUOROQUINOLINE;1188002-20-1;DTXSID00700078;AKOS013528220;CS-0246396;EN300-3238895

Suppliers and Price of 2-Chloro-5,7-difluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
2-Chloro-5,7-difluoroquinoline
2.5g
$ 1420.00

AK Scientific
2-Chloro-5,7-difluoroquinoline
250mg
$ 370.00

AK Scientific
2-Chloro-5,7-difluoroquinoline
100mg
$ 289.00

Total 3 raw suppliers

Chemical Property of 2-Chloro-5,7-difluoroquinoline

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:199.0000331
Heavy Atom Count:13
Complexity:191

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5,7-difluoroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=NC2=C1C(=CC(=C2)F)F)Cl

Technology Process of 2-Chloro-5,7-difluoroquinoline

There total 5 articles about 2-Chloro-5,7-difluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 917341-46-9
5,7-difluoroquinolin-2-one

: 1188002-20-1
2-chloro-5,7-difluoroquinoline

Guidance literature:: With trichlorophosphate; at 95 - 100 ℃; for 2h;
DOI:10.1016/j.tet.2017.01.026

Reference yield:

: 372-39-4
3,5-difluoroaniline

: 1188002-20-1
2-chloro-5,7-difluoroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water; acetone / 3 h / 0 - 20 °C

2: aluminum (III) chloride / 2 h / 110 - 120 °C

3: trichlorophosphate / 2 h / 95 - 100 °C

With aluminum (III) chloride; potassium carbonate; trichlorophosphate; In water; acetone;
DOI:10.1016/j.tet.2017.01.026

Reference yield:

: 319-88-0
1,3,5-trichlorotrifluorobenzene

: 1188002-20-1
2-chloro-5,7-difluoroquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / 3 h / -70 °C

2: zinc; ammonia; copper / water / 24 h / 25 °C

3: potassium carbonate / water; acetone / 3 h / 0 - 20 °C

4: aluminum (III) chloride / 2 h / 110 - 120 °C

5: trichlorophosphate / 2 h / 95 - 100 °C

With aluminum (III) chloride; ammonia; copper; potassium carbonate; zinc; trichlorophosphate; In water; acetone;
DOI:10.1016/j.tet.2017.01.026