((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene

Base Information

• Chemical Name: ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene
• CAS No.: 137298-97-6
• Molecular Formula: C₃₉H₇₂O₅Si₂
• Molecular Weight: 677.169

Synonyms:

Chemical Property of ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene

There total 4 articles about ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyloxymethyl chloride (3587-60-8) → ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene (137298-97-6,137332-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) t-BuOOH, 2) DIPEA / 1) V(O)acac2 / 1) CH₂Cl₂, 2) CH₂Cl₂

2: CuCN / diethyl ether / -40 - -20 °C

3: 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; bis(acetylacetonate)oxovanadium; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)92266-4

Reference yield:

(2R,3S)-1-[(1S,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-hex-5-en-3-ol (131719-87-4) → ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene (137298-97-6,137332-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) t-BuOOH, 2) DIPEA / 1) V(O)acac2 / 1) CH₂Cl₂, 2) CH₂Cl₂

2: CuCN / diethyl ether / -40 - -20 °C

3: 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; bis(acetylacetonate)oxovanadium; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)92266-4

Reference yield:

[(1R,2R,4S)-4-((2R,3S)-3-Benzyloxymethoxy-2-methyl-4-oxiranyl-butyl)-2-methoxy-cyclohexyloxy]-tert-butyl-dimethyl-silane (137298-96-5,137332-25-3) → ((1S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-{(R)-2-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl}-non-8-enyloxymethoxymethyl)-benzene (137298-97-6,137332-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CuCN / diethyl ether / -40 - -20 °C

2: 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)92266-4

upstream raw materials:

t-butyldimethylsiyl triflate

(2R,3S,5S)-3-Benzyloxymethoxy-1-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-undec-10-en-5-ol

Benzyloxymethyl chloride

(2R,3S)-1-[(1S,3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-2-methyl-hex-5-en-3-ol

Downstream raw materials:

(1R,9S,12S,14S,24R,27R)-1,14-Dihydroxy-12-[(R)-2-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-27-methyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacosane-2,3,10,20-tetraone

(7S,9S,10R)-9-Benzyloxymethoxy-7-(tert-butyl-dimethyl-silanyloxy)-11-[(1S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-10-methyl-undecanoic acid methyl ester

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