1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester
• CAS No.: 30932-85-5
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Hs Code.: 2933998090
• Mol file: 30932-85-5.mol

Synonyms:

Chemical Property of 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-Methyl-2-oxopyrrolidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

There total 3 articles about 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + Diethyl carbonate (105-58-8,76619-83-5) → 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester (30932-85-5)

Guidance literature:

1-methyl-pyrrolidin-2-one; With sodium hydride; In toluene; at 0 ℃; for 1h; Inert atmosphere;

Diethyl carbonate; In toluene; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.5b03080

Reference yield: 48.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + chloroformic acid ethyl ester (541-41-3) → 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester (30932-85-5)

Guidance literature:

1-methyl-pyrrolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00041

Reference yield:

→ 1-methyl-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester (30932-85-5)

Guidance literature:

1-Methyl-2-pyrrolidinon, Kohlensaeure-diethylester;

DOI:10.1021/ja00754a056

upstream raw materials:

1-methyl-pyrrolidin-2-one

Diethyl carbonate

chloroformic acid ethyl ester

Downstream raw materials:

3-(hydroxymethyl)-1-methylpyrrolidin-2-one

1-methyl-2-oxo-pyrrolidine-3-carboxylic acid

2-oxopyrrolidine-3-carboxylic acid