2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate
• CAS No.: 1373945-02-8
• Molecular Formula: C₂₄H₂₅F₃O₄SSi
• Molecular Weight: 496.591
• Mol file: 1373945-02-8.mol

Synonyms:

Chemical Property of 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate

There total 4 articles about 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + C23H24(2)H2O2Si → 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate (1373945-02-8)

Guidance literature:

C₂₃H₂₄⁽²⁾H₂O₂Si; With n-butyllithium; In diethyl ether; hexane; at -75 ℃; for 0.5h; Inert atmosphere;

trifluoromethylsulfonic anhydride; In diethyl ether; at -75 - 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1021/ja302278s

Reference yield:

2-deuteriochlorobenzene (19256-46-3) → 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate (1373945-02-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 6 h / 20 - 80 °C / Inert atmosphere

1.2: 0.42 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; pentane / 0.75 h / -75 - 20 °C / Inert atmosphere

2.2: 12.5 h / -75 - 30 °C / Inert atmosphere

3.1: 1H-imidazole / tetrahydrofuran / 40 h / 20 - 30 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -75 - 20 °C / Inert atmosphere

5.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -75 °C / Inert atmosphere

5.2: 1.25 h / -75 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; magnesium; ethylene dibromide; In tetrahydrofuran; diethyl ether; hexane; pentane;

DOI:10.1021/ja302278s

Reference yield:

C16H17(2)H2ClSi → 2-(tert-butyl)-bis(2-deuteriophenyl)silyl-3-methoxyphenyl trifluoromethanesulfonate (1373945-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / tetrahydrofuran / 40 h / 20 - 30 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -75 - 20 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -75 °C / Inert atmosphere

3.2: 1.25 h / -75 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ja302278s

upstream raw materials:

trifluoromethylsulfonic anhydride

2-deuteriochlorobenzene

1-bromo-2-deuterobenzene