7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran

Base Information

• Chemical Name: 7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran
• CAS No.: 145653-89-0
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.224

Synonyms:

Chemical Property of 7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran

Chemical Property:

Purity/Quality:

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Technology Process of 7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran

There total 1 articles about 7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

nitromethane (75-52-5) + 4-formyl-7-methoxy-2-methylbenzofuran (130627-28-0) → 7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran (145653-89-0)

Guidance literature:

With ammonium acetate; In acetic acid; for 1.5h; Heating;

DOI:10.1248/cpb.40.1993

Reference yield:

7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran (145653-89-0) → 6-(2-N-carbo-tert-butoxyaminoethyl)-2,3-dimethoxybenzyl alcohol

Guidance literature:

Multi-step reaction with 7 steps

1: LiAlH₄ / tetrahydrofuran; diethyl ether / 0.83 h / Heating

2: 76 percent / 10percent NaOH / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 98 percent / 4-dimethylaminopyridine / acetonitrile / 67 h / Ambient temperature

4: 1.) OsO₄, pyridine, 2.) sodium hydrogen sulfite / 1.) RT, 3.5 h, 2.) water, RT, 2.5 h

5: 76 percent / NaIO₄ / methanol; H₂O / 0.08 h / Ambient temperature

6: 100 percent / K₂CO₃ / dimethylformamide / 2 h / 40 °C

7: 78 percent / H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

With pyridine; dmap; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; sodium hydrogensulfite; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.40.1993

Reference yield:

7-methoxy-2-methyl-4-(2-nitrovinyl)benzofuran (145653-89-0) → 4-(2-N,O-dicarbobenzoxyhydroxyaminoethyl)-7-methoxy-2-methylbenzofuran

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran; diethyl ether / 0.83 h / Heating

2: 3 percent / 10percent NaOH / CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1248/cpb.40.1993

upstream raw materials:

nitromethane

4-formyl-7-methoxy-2-methylbenzofuran

Downstream raw materials:

1,2,3,4-tetrahydro-7,8-dimethoxyisoquinoline

4-(2-N-carbobenzoxyaminoethyl)-7-methoxy-2-methylbenzofuran

2-carbobenzoxy-1,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline

4-(2-N-carbobenzoxyaminoethyl)-2,3-dihydroxy-7-methoxy-2-methyl-2,3-dihydrobenzofuran

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