(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

Base Information

Chemical Name:(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester
CAS No.:679000-74-9
Molecular Formula:C₃₃H₃₈Cl₃NO₆
Molecular Weight:651.027
Hs Code.:

(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

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Chemical Property of (2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

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Technology Process of (2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

There total 5 articles about (2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94061-58-2
furanol

: 420834-18-0
3-(2,2,2-trichloroethoxycarbonyl)-2-cyclohexyl-4-phenyl-5-oxazolidinecarboxylic acid

: 679000-74-9
(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 20 ℃;

Reference yield:

: 132201-32-2,161453-08-3,949459-75-0,521059-43-8
(2R,3S)-3-phenylisoserine hydrochloride

: 679000-74-9
(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / SOCl₂ / 0 °C

2: NaHCO₃ / CH₂Cl₂

3: p-TsOH / toluene / 110 °C

4: LiOH / methanol

5: DCC; DMAP / toluene / 20 °C

With dmap; lithium hydroxide; thionyl chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; toluene;

Reference yield:

: methyl (2R,3S)-3-phenylisoserinate hydrochloride

: 679000-74-9
(2R,3S)-3-Phenyl-1-oxa-4-aza-spiro[4.5]decane-2,4-dicarboxylic acid 4-(2,2,2-trichloro-ethyl) ester 2-((4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / CH₂Cl₂

2: p-TsOH / toluene / 110 °C

3: LiOH / methanol

4: DCC; DMAP / toluene / 20 °C

With dmap; lithium hydroxide; sodium hydrogencarbonate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; toluene;