(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

Base Information

Chemical Name:(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid
CAS No.:130796-35-9
Molecular Formula:C₁₂H₁₄O₄
Molecular Weight:222.241
Hs Code.:

Synonyms:

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Chemical Property of (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

Chemical Property:

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Technology Process of (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

There total 10 articles about (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 130796-32-6
(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

: 130796-35-9
(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

Guidance literature:: With silver(l) oxide; Ambient temperature;

Reference yield:

: 20698-91-3
(R)-methyl mandelate

: 130796-35-9
(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature

2: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

3: 97 percent / zinc borohydride / diethyl ether / 1 h / -78 °C

4: 98 percent / 4-toluenesulfonic acid / Ambient temperature

5: 79 percent / yellow mercuric oxide, Bf₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 50 percent / K₂CO₃, methanol / 2 h / -5 °C

7: 50 percent / silver oxide / Ambient temperature

With 1H-imidazole; methanol; dmap; n-butyllithium; zinc borohydride; boron trifluoride diethyl etherate; potassium carbonate; toluene-4-sulfonic acid; mercury(II) oxide; silver(l) oxide; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 109459-35-0
methyl (R)-2-phenyl-2-((trimethylsilyl)oxy)acetate

: 130796-35-9
(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

2: 97 percent / zinc borohydride / diethyl ether / 1 h / -78 °C

3: 98 percent / 4-toluenesulfonic acid / Ambient temperature

4: 79 percent / yellow mercuric oxide, Bf₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

5: 50 percent / K₂CO₃, methanol / 2 h / -5 °C

6: 50 percent / silver oxide / Ambient temperature

With methanol; n-butyllithium; zinc borohydride; boron trifluoride diethyl etherate; potassium carbonate; toluene-4-sulfonic acid; mercury(II) oxide; silver(l) oxide; In tetrahydrofuran; diethyl ether; water;