109459-35-0

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 20698-91-3 (R)-methyl mandelate 

Downstream Products

• 130718-68-2 (R)-3-hydroxy-3-phenyl-1,1-bis(p-tolylthio)propan-2-one 
• 130718-66-0 (R)-3-phenyl-1,1-bis(p-tolylthio)-3-(trimethylsilyloxy)propan-2-one 
• 34025-29-1 (R)-2-hydroxy-2-phenylacetaldehyde 
• 109459-40-7 Cyclohexane-1,2-dicarboxylic acid 1-((R)-methoxycarbonyl-phenyl-methyl) ester 2-methyl ester 
• 124649-67-8 methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate 
• 130796-32-6 (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde 
• 130718-77-3 (4R,5R)-cis-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde 
• 130796-35-9 (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid 
• 130718-78-4 (4R,5R)-cis-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid 
• 130796-40-6 (2R,3R)-2,3-dihydroxy-3-phenylpropanoic acid methyl ester 
• 130796-37-1 (4S,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester 
• 130718-79-5 (4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester 
• 130718-71-7 erythro (2R,3R)-3-phenyl-1,1-bis(p-tolylthio)propane-2,3-diol 
• 130718-73-9 threo (2S,3R)-3-phenyl-1,1-bis(p-tolylthio)propane-2,3-diol 

Relevant academic research and scientific papers

Synthesis of Enantiomerically Pure α-Hydroxyaldehydes from the Corresponding α-Hydroxycarboxylic acids: Novel Substrates for Escherichia coli Transketolase

Enantiomerically pure (R)-α-hydroxyaldehydes (>95percent ee) are prepared from the corresponding α-hydroxyesters by silyl protection, reduction with diisobutylaluminium hydride, and finally deprotection under acidic conditions; subsequent coupling of these aldehydes with lithium hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.

Synthesis of Aryl Carbohydrate Synthons and 2,3-Dihydroxypropanoic Acid Derivatives of High Optical Purity

General routes to bith L and D aryl carbohydrate precursors and to erythro and threo 2,3-dihydroxypropanoic acid of high optical purity have been established from readily available optically active aryl cyanohydrins.