2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide

Base Information

• Chemical Name: 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide
• CAS No.: 138036-59-6
• Molecular Formula: C₃₉H₄₂F₆N₄O₇S
• Molecular Weight: 824.841

Synonyms:

Chemical Property of 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide

There total 2 articles about 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoro-1,1-diphenylethanesulfenamide (112882-16-3) → 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide (138036-59-6,138127-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridinium p-toluenesulfonate, MgSO₄ / CH₂Cl₂ / 2 h

2: 1) NOCl / 1) CH₂Cl₂, -70 deg C; 2) DMF

With pyridinium p-toluenesulfonate; magnesium sulfate; nitrosylchloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)91009-9

Reference yield:

(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran (91704-05-1) + 3-aminobut-2-enoic methylester (138036-56-3) → 2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide (138036-59-6,138127-78-3)

Guidance literature:

With nitrosylchloride; Multistep reaction; 1) CH₂Cl₂, -70 deg C; 2) DMF;

DOI:10.1016/S0040-4020(01)91009-9

Reference yield:

2,2,2-Trifluoro-N-{(2S,6R)-5-[(E)-hydroxyimino]-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-N-((R)-1-phenyl-ethyl)-acetamide (138036-59-6,138127-78-3) → N-{(2S,5R,6R)-5-Amino-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide (138036-60-9,138230-45-2)

Guidance literature:

With molybdenum(VI) oxide; In methanol; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91009-9

upstream raw materials:

(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

3-aminobut-2-enoic methylester

2,2,2-trifluoro-1,1-diphenylethanesulfenamide

Downstream raw materials:

N-{(2S,5R,6R)-5-Amino-6-[(3aR,4S,6S,7R,7aR)-4-methoxy-3-methyl-2-oxo-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-octahydro-benzooxazol-7-yloxy]-tetrahydro-pyran-2-ylmethyl}-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide

(3aR,4S,6S,7R,7aR)-7-{(2R,3R,6S)-3-Amino-6-[((R)-1-phenyl-ethylamino)-methyl]-tetrahydro-pyran-2-yloxy}-4-methoxy-3-methyl-6-(2,2,2-trifluoro-1,1-diphenyl-ethylsulfanylamino)-hexahydro-benzooxazol-2-one

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