1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

Base Information

• Chemical Name: 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol
• CAS No.: 144490-20-0
• Molecular Formula: C₆₀H₈₁NO₅Si₂
• Molecular Weight: 952.478

Synonyms:

Chemical Property of 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

There total 1 articles about 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Nitroethane (79-24-3) + 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-30-5) → 1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-31-6,144490-20-0)

Guidance literature:

With phenyl isocyanate; In toluene;

DOI:10.1016/S0040-4039(00)61222-4

Reference yield: 36.0%

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-31-6,144490-20-0) → (2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanone (144396-33-8) + 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one (144396-32-7,144490-21-1)

Guidance literature:

With hexacarbonyl molybdenum; water; In acetonitrile;

DOI:10.1016/S0040-4039(00)61222-4

Reference yield:

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-31-6,144490-20-0) → (1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(S)-2-(2-Hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethyl}-cyclohex-4-ene-1,3-diol (144396-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / Mo(CO)6, H₂O / acetonitrile

2: 79 percent / CH₃COOH

3: 71 percent / NaBH₄, acetic acid

4: 67 percent / TBAF / tetrahydrofuran

With sodium tetrahydroborate; hexacarbonyl molybdenum; tetrabutyl ammonium fluoride; water; acetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4039(00)61222-4

upstream raw materials:

Nitroethane

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

Downstream raw materials:

(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanone

1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one

(1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(S)-2-(2-Hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethyl}-cyclohex-4-ene-1,3-diol

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

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