Technology Process of 9-methoxy-2-methylthio-6-tosyl-3,4,5,6-tetrahydro-1,3,6-benzotriazocine
There total 4 articles about 9-methoxy-2-methylthio-6-tosyl-3,4,5,6-tetrahydro-1,3,6-benzotriazocine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) NaOMe / 1) methanol, reflux, 0.5 h, 2) DMF, 120 deg C, 12 h
2: 62 percent / ammonia / ethanol / 5 h / 130 °C / in a sealed vessel
3: 1) H2 / 1) 8percent Pd-C / 1) dioxane, 2) dioxane, reflux, 0.5 h, 3) MeOH, 4 deg C, several hours
4: 1) NaOMe / 1) MeOH, 2) MeOH, reflux, 3 h
With
ammonia; hydrogen; sodium methylate;
palladium on activated charcoal;
In
ethanol;
DOI:10.1016/S0040-4020(01)91885-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 62 percent / ammonia / ethanol / 5 h / 130 °C / in a sealed vessel
2: 1) H2 / 1) 8percent Pd-C / 1) dioxane, 2) dioxane, reflux, 0.5 h, 3) MeOH, 4 deg C, several hours
3: 1) NaOMe / 1) MeOH, 2) MeOH, reflux, 3 h
With
ammonia; hydrogen; sodium methylate;
palladium on activated charcoal;
In
ethanol;
DOI:10.1016/S0040-4020(01)91885-X
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) H2 / 1) 8percent Pd-C / 1) dioxane, 2) dioxane, reflux, 0.5 h, 3) MeOH, 4 deg C, several hours
2: 1) NaOMe / 1) MeOH, 2) MeOH, reflux, 3 h
With
hydrogen; sodium methylate;
palladium on activated charcoal;
DOI:10.1016/S0040-4020(01)91885-X
