4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

Base Information

Chemical Name:4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester
CAS No.:1190713-15-5
Molecular Formula:C₃₀H₃₉N₅O₇
Molecular Weight:581.669
Hs Code.:

4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

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Chemical Property of 4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

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Technology Process of 4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

There total 11 articles about 4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190713-25-7
3.3. 4-((S)-4-tert-butoxycarbonyl-2-{[6-((1S,2S)-2-methoxymethyl-cyclopropyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

: 1190713-15-5
4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.06.070

Reference yield:

: C₁₈H₂₀N₂O₃

: 1190713-15-5
4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: water; potassium carbonate / methanol / 20 °C

2: potassium permanganate; sodium hydroxide / water; 1,4-dioxane / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With potassium permanganate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2014.06.070

Reference yield:

: 592-34-7
carbonochloridic acid, butyl ester

: 1190713-15-5
4-((S)-4-carboxy-2-{[6-((1S,2S)-2-methoxymethylcyclopropyl)-2-phenylpyrimidine-4-carbonyl]amino}butyryl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 20 °C

4: palladium on activated charcoal; hydrogen / ethanol / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.070