N-(n-butoxycarbonyl)piperazine

Base Information

• Chemical Name: N-(n-butoxycarbonyl)piperazine
• CAS No.: 50606-32-1
• Molecular Formula: C9H18N2O2
• Molecular Weight: 186.254
• Hs Code.: 2933599090
• Mol file: 50606-32-1.mol

Synonyms:N-butoxycarbonylpiperazine;piperazine-1-carboxylic acid butyl ester;1-butyloxycarbonylpiperazine;butyloxycarbonylpiperazine;N-(n-butoxycarbonyl)piperazine;1-Piperazinecarboxylic acid,butyl ester;1-butoxycarbonylpiperazine;butoxycarbonylpiperazine;

Chemical Property of N-(n-butoxycarbonyl)piperazine

Chemical Property:

• Boiling Point: 141-143 °C(Press: 10 Torr)
• PKA: 8.45±0.10(Predicted)
• PSA: 41.57000
• Density: 1.030±0.06 g/cm3(Predicted)
• LogP: 1.09500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Butylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(n-butoxycarbonyl)piperazine

There total 5 articles about N-(n-butoxycarbonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperazine-1,4-dicarboxylic acid tert-butyl ester butyl ester (1073554-07-0) → 1-butyloxycarbonylpiperazine (50606-32-1)

Guidance literature:

piperazine-1,4-dicarboxylic acid tert-butyl ester butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=10;

DOI:10.1021/jm901518t

Reference yield: 96.0%

4-benzylpiperazine-1-carboxylic acid butyl ester (1019928-96-1) → 1-butyloxycarbonylpiperazine (50606-32-1)

Guidance literature:

With 5%-palladium/activated carbon; In ethanol; for 24h;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

carbonochloridic acid, butyl ester (592-34-7) → 1-butyloxycarbonylpiperazine (50606-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2014.06.070

upstream raw materials:

piperazine

carbonochloridic acid, butyl ester

4-benzylpiperazine-1-carboxylic acid butyl ester

piperazine-1,4-dicarboxylic acid tert-butyl ester butyl ester

Downstream raw materials:

4-[2-benzyloxycarbonylamino-2-(dimethoxy-phosphoryl)-acetyl]-piperazine-1-carboxylic acid butyl ester

butyl (S)-4-(2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

3.3. 4-((S)-4-tert-butoxycarbonyl-2-{[6-((1S,2S)-2-methoxymethyl-cyclopropyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 50606-32-1 N-(n-butoxycarbonyl)piperazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send