4-benzylpiperazine-1-carboxylic acid butyl ester

Base Information

• Chemical Name: 4-benzylpiperazine-1-carboxylic acid butyl ester
• CAS No.: 1019928-96-1
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.379
• Mol file: 1019928-96-1.mol

Synonyms:4-benzylpiperazine-1-carboxylic acid butyl ester

Chemical Property of 4-benzylpiperazine-1-carboxylic acid butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-benzylpiperazine-1-carboxylic acid butyl ester

There total 1 articles about 4-benzylpiperazine-1-carboxylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenylmethylpiperazine (2759-28-6) + carbonochloridic acid, butyl ester (592-34-7) → 4-benzylpiperazine-1-carboxylic acid butyl ester (1019928-96-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield: 96.0%

4-benzylpiperazine-1-carboxylic acid butyl ester (1019928-96-1) → 1-butyloxycarbonylpiperazine (50606-32-1)

Guidance literature:

With 5%-palladium/activated carbon; In ethanol; for 24h;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

4-benzylpiperazine-1-carboxylic acid butyl ester (1019928-96-1) → C34H48N6O7

Guidance literature:

Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 20 °C

3: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4: triethylamine / acetonitrile / 0 - 20 °C

5: triethylamine / tetrahydrofuran / 40 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2014.06.070

upstream raw materials:

1-phenylmethylpiperazine

carbonochloridic acid, butyl ester

Downstream raw materials:

1-butyloxycarbonylpiperazine

butyl (S)-4-(2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

3.3. 4-((S)-4-tert-butoxycarbonyl-2-{[6-((1S,2S)-2-methoxymethyl-cyclopropyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester