Technology Process of N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-N-isopropenyl-S-trityl-thiohydroxylamine
There total 3 articles about N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-N-isopropenyl-S-trityl-thiohydroxylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / Sulfuryl chloride / toluene; diethyl ether / 2 h / 0 °C
2: 78 percent / 29 percent NH4OH/H2O / CH2Cl2 / 0 °C
3: 98 percent / Pridinium p-toluenesulfonate, (PPTS)/anhydr. MgSO4 / CH2Cl2 / 2 h / Ambient temperature
4: 1.) sec-BuLi, 2.) HMPT / 1.) THF, -20 deg C, 15 min, 2.) THF, -20 deg C, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; sulfuryl dichloride; water; sec.-butyllithium; pyridinium p-toluenesulfonate; magnesium sulfate;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00168a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / 29 percent NH4OH/H2O / CH2Cl2 / 0 °C
2: 98 percent / Pridinium p-toluenesulfonate, (PPTS)/anhydr. MgSO4 / CH2Cl2 / 2 h / Ambient temperature
3: 1.) sec-BuLi, 2.) HMPT / 1.) THF, -20 deg C, 15 min, 2.) THF, -20 deg C, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; water; sec.-butyllithium; pyridinium p-toluenesulfonate; magnesium sulfate;
In
dichloromethane;
DOI:10.1021/jo00168a031
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sec.-butyllithium;
Yield given. Multistep reaction;
1.) THF, -20 deg C, 15 min, 2.) THF, -20 deg C, 1 h;
DOI:10.1021/jo00168a031
