(1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine

Base Information

• Chemical Name: (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine
• CAS No.: 1201788-28-4
• Molecular Formula: C₁₀H₁₃FINO
• Molecular Weight: 309.122
• Mol file: 1201788-28-4.mol

Synonyms:

Chemical Property of (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine

There total 1 articles about (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol (927689-70-1) + methyl iodide (74-88-4) → (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine (1201788-28-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -25 - -20 ℃; for 3.66667h;

DOI:10.1021/op900252a

Reference yield:

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine (402960-38-7) + (1S,2R)-1-fluoromethyl-2-(4-iodophenyl)-2-methoxyethylamine (1201788-28-4) → 5-[4-((1R,2S)-(2-amino-3-fluoro-1-methoxypropyl))phenyl]pyrimidin-2-ylamine dihydrochloride

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 70 ℃; Inert atmosphere; Reflux;

DOI:10.1021/op900252a

upstream raw materials:

(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

methyl iodide