DesMethyl FluoroMetholone

Base Information

• Chemical Name: DesMethyl FluoroMetholone
• CAS No.: 426-20-0
• Molecular Formula: C₂₁H₂₇FO₄
• Molecular Weight: 362.441
• Mol file: 426-20-0.mol

Synonyms:

Chemical Property of DesMethyl FluoroMetholone

Chemical Property:

• Melting Point: >173°C (dec.)
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

DesmethylFluorometholone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Desmethyl Fluorometholone acts as a glucocorticoid, a steroid for treatment of ocular inflammation. It is an impurity of Fluorometholone (F593145) synthesis.

Technology Process of DesMethyl FluoroMetholone

There total 11 articles about DesMethyl FluoroMetholone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-fluoro-11β,17-dihydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione (382-66-1) → 9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione (426-20-0)

Guidance literature:

With acetic acid; sodium iodide;

DOI:10.1021/ja01620a076

Reference yield:

fludrocortisone acetate (514-36-3) → 9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione (426-20-0)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium / Hydrogenation

2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin

3: aqueous methanol.K₂CO₃

5: NaI; acetic acid

With bromine; potassium carbonate; palladium; acetic acid; sodium iodide;

DOI:10.1021/ja01620a076

Reference yield:

prednisolone 21-acetate (52-21-1) → 9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione (426-20-0)

Guidance literature:

Multi-step reaction with 7 steps

1: methanesulfonyl chloride; pyridine

2: aqueous HClO₄

3: potassium acetate; ethanol

4: HF

5: aqueous methanol.K₂CO₃

7: NaI; acetic acid

With pyridine; perchloric acid; ethanol; hydrogen fluoride; potassium acetate; potassium carbonate; acetic acid; methanesulfonyl chloride; sodium iodide;

DOI:10.1021/ja01620a076

upstream raw materials:

9-fluoro-11β,17-dihydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione

fludrocortisone acetate

prednisolone 21-acetate

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate