Ak-Tate

Base Information

Chemical Name:Ak-Tate
CAS No.:52-21-1
Molecular Formula:C23H30O6
Molecular Weight:402.488
Hs Code.:29372900
European Community (EC) Number:200-134-1
Mol file:52-21-1.mol

Synonyms:pred forte;prednisolone 21-acetate;prednisolone acetate;Scherisolone-Kristall suspension

Suppliers and Price of Ak-Tate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Prednisolone acetate
2g
$ 120.00

Sigma-Aldrich
Prednisolone 21-acetate ≥97%
1g
$ 54.60

Sigma-Aldrich
Prednisolone acetate Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 108.00

Sigma-Aldrich
Prednisolone acetate United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Sigma-Aldrich
Prednisolone acetate for peak identification European Pharmacopoeia (EP) Reference Standard
y0000582
$ 190.00

Sigma-Aldrich
Prednisolone acetate European Pharmacopoeia (EP) Reference Standard
p2800000
$ 190.00

Sigma-Aldrich
Prednisolone 21-acetate ≥97%
5g
$ 188.00

Crysdot
Prednisolone 21-acetate 98+%
5g
$ 129.00

Crysdot
Prednisolone 21-acetate 98+%
1g
$ 59.00

Crysdot
Prednisolone 21-acetate 98+%
250mg
$ 40.00

Total 185 raw suppliers

Chemical Property of Ak-Tate

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:7.36E-16mmHg at 25°C
Melting Point:240-244 °C
Refractive Index:112 ° (C=1, Dioxane)
Boiling Point:579.8 °C at 760 mmHg
PKA:12.41±0.70(Predicted)
Flash Point:198.4 °C
PSA：100.90000
Density:1.28 g/cm³
LogP:2.12840
Storage Temp.:2-8°C
Solubility.:Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride.
Water Solubility.:11.6mg/L(25 oC)
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:402.20423867
Heavy Atom Count:29
Complexity:827

Purity/Quality:

99%, ^*data from raw suppliers

Prednisolone acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,C,F
Hazard Codes:T,C,F
Statements: 25-34-11
Safety Statements: 45-36/37/39-26-16

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)O
Isomeric SMILES:CC(=O)OCC(=O)[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)O
Recent ClinicalTrials:DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia
Recent EU Clinical Trials:Effect of drop-less surgery compared to topical NSAID alone and combination of steroid and NSAID on central macular thickness after cataract surgery, a randomized controlled trial
Uses Synthetic corticosteroid; metabolically interconvertible with prednisone.
Therapeutic Function Glucocorticoid
Clinical Use For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.

Technology Process of Ak-Tate

There total 19 articles about Ak-Tate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 50-24-8,8056-11-9
prednisolon

: 108-24-7
acetic anhydride

: 52-21-1
prednisolone 21-acetate

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 40 ℃; for 0.5h; Inert atmosphere;

Reference yield: 92.0%

: 4224-31-1
21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

: 52-21-1
prednisolone 21-acetate

Guidance literature:: 21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione; With chromium(VI) oxide; mercaptoacetic acid; zinc; In dimethyl sulfoxide; acetone; at 15 - 20 ℃;

With hydrogenchloride; In water; for 1h;

With sodium thiosulfate; In water; for 0.333333h; Reagent/catalyst;