514-36-3 Usage
Uses
Used in Pharmaceutical Industry:
Fludrocortisone acetate is used as a medication for the treatment of Addison's disease, a condition characterized by insufficient production of adrenal hormones. Its potent mineralocorticoid activity promotes sodium retention and potassium excretion, helping to maintain electrolyte balance in patients with this condition.
Additionally, Fludrocortisone acetate is used as a partial replacement therapy for primary and secondary adrenocortical insufficiency, as well as for the treatment of salt-losing adrenal hyperplasia. Its glucocorticoid actions, which are about 10 times as potent as hydrocortisone, contribute to its effectiveness in these applications.
Biochem/physiol Actions
Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.
Clinical Use
Replacement therapy in adrenal insufficiency
Veterinary Drugs and Treatments
Fludrocortisone is used in small animal medicine for the treatment
of adrenocortical
insufficiency (Addison’s disease). It can also be
used as adjunctive therapy in hyperkalemia.
Additionally, in humans, fludrocortisone has been used in saltlosing,
congenital adrenogenital syndrome
and in patients with severe
postural hypotension.
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifamycins;
metabolism possibly inhibited by erythromycin;
possibly reduce isoniazid concentration.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by
ritonavir.
Cobicistat: concentration of fludrocortisone
increased.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines
Metabolism
Fludrocortisone is hydrolysed to produce the nonesterified alcohol. In human volunteers, excretion through
urine was about 80%, and it was concluded that about
20% were excreted by a different route. It is likely that, as
for the metabolism of other steroids, excretion into the
bile is balanced by re-absorption in the intestine and some
part is excreted with the faeces
Check Digit Verification of cas no
The CAS Registry Mumber 514-36-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 514-36:
(5*5)+(4*1)+(3*4)+(2*3)+(1*6)=53
53 % 10 = 3
So 514-36-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
514-36-3Relevant academic research and scientific papers
Method for preparing hydrocortisone acetate
-
Paragraph 0021-0038, (2018/04/28)
The invention relates to a method for preparing hydrocortisone acetate. The method comprises the following steps: 9beta, 11beta-epoxy-17alpha-dihydroxypregn-4-ene-3,20-dione-21-acetate is subjected toa ring-opening reaction with a fluorinating reagent, wherein the fluorinating reagent is an organic amine salt or solution of hydrogen fluoride. The reagent and conditions for ring-opening fluorination of epoxy compounds in key process steps are mainly improved, organic amine salt of hydrogen fluoride substitutes for high-toxicity and high-corrosiveness hydrogen fluoride gas, a small quantity ofthe fluorinating reagent is used, and the method is safe and convenient to operate and suitable for industrial production.
Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
-
, (2008/06/13)
This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.
