Technology Process of 3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine hydrochloride
There total 7 articles about 3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 62 g / K2CO3 / ethanol / 10 h / Heating
2: 29.6 g / borane-methyl sulfide complex / tetrahydrofuran / 12 h / Heating
3: 41 g / pyridine / 12 h / 0 °C
4: 79 percent / dimethylformamide / 36 h / 65 °C
5: 98 percent / 85percent hydrazine hydrate, Raney nickel / ethanol / 0.5 h / Heating
6: pyridine / ice cooling -> room temperature
7: 1.) hydrogen, 2.) HCl / 1.) 10percent Pd/C / 1.) MeOH, 60 psi, 12 h
With
hydrogenchloride; dimethylsulfide borane complex; hydrogen; nickel; potassium carbonate; hydrazine hydrate;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600760515
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 41 g / pyridine / 12 h / 0 °C
2: 79 percent / dimethylformamide / 36 h / 65 °C
3: 98 percent / 85percent hydrazine hydrate, Raney nickel / ethanol / 0.5 h / Heating
4: pyridine / ice cooling -> room temperature
5: 1.) hydrogen, 2.) HCl / 1.) 10percent Pd/C / 1.) MeOH, 60 psi, 12 h
With
hydrogenchloride; hydrogen; nickel; hydrazine hydrate;
palladium on activated charcoal;
In
pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600760515
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / 85percent hydrazine hydrate, Raney nickel / ethanol / 0.5 h / Heating
2: pyridine / ice cooling -> room temperature
3: 1.) hydrogen, 2.) HCl / 1.) 10percent Pd/C / 1.) MeOH, 60 psi, 12 h
With
hydrogenchloride; hydrogen; nickel; hydrazine hydrate;
palladium on activated charcoal;
In
pyridine; ethanol;
DOI:10.1002/jps.2600760515
