4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine

Base Information

• Chemical Name: 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine
• CAS No.: 96886-51-0
• Molecular Formula: C₂₁H₂₈N₂O₃
• Molecular Weight: 356.465
• Mol file: 96886-51-0.mol

Synonyms:4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine

Chemical Property of 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine

There total 12 articles about 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

di-n-propylamine (142-84-7) + Toluene-4-sulfonic acid 2-(4-benzyloxy-3-nitro-phenyl)-ethyl ester (110925-46-7) → 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine (96886-51-0)

Guidance literature:

In N,N-dimethyl-formamide; at 65 ℃; for 36h;

DOI:10.1002/jps.2600760515

Reference yield:

4-(2-dipropylamino-ethyl)-phenol (96886-46-3) → 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine (96886-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / aq. HNO₃ / acetic acid / Ambient temperature

2: K₂CO₃ / acetone / 2 h / Heating

With nitric acid; potassium carbonate; In acetic acid; acetone;

DOI:10.1021/jm00156a010

Reference yield:

di-n-propylamine (142-84-7) → 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine (96886-51-0)

Guidance literature:

Multi-step reaction with 5 steps

1: CHCl₃ / 2 h / 50 °C

2: diborane/THF / 4 h / Heating

3: 48percent aq. HBr / 4 h / Heating

4: 48 percent / aq. HNO₃ / acetic acid / Ambient temperature

5: K₂CO₃ / acetone / 2 h / Heating

With tetrahydrofuran; hydrogen bromide; nitric acid; potassium carbonate; diborane; In chloroform; acetic acid; acetone;

DOI:10.1021/jm00156a010

upstream raw materials:

benzyl bromide

4-hydroxy-3-nitro-N,N-di-n-propylphenethylamine

di-n-propylamine

Toluene-4-sulfonic acid 2-(4-benzyloxy-3-nitro-phenyl)-ethyl ester

Downstream raw materials:

3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine

N-[2-Benzyloxy-5-(2-dipropylamino-ethyl)-phenyl]-methanesulfonamide

2-benzyloxy-5-(2-N,N-di-n-propylaminoethyl)ureidobenzene

3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine hydrochloride