(R)-butyl methylphenylphosphine oxide

Base Information

Chemical Name:(R)-butyl methylphenylphosphine oxide
CAS No.:87219-93-0
Molecular Formula:C₁₁H₁₇OP
Molecular Weight:196.229
Hs Code.:

Synonyms:

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Chemical Property of (R)-butyl methylphenylphosphine oxide

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Technology Process of (R)-butyl methylphenylphosphine oxide

There total 15 articles about (R)-butyl methylphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 693-03-8
n-butyl magnesium bromide

: 87219-86-1
(R)-Methyl-phenyl-phosphinic acid (S)-3-iodo-1-methyl-propyl ester

: 87219-93-0
(R)-butyl methylphenylphosphine oxide

Guidance literature:: In diethyl ether; benzene; at 80 ℃; for 5h;
DOI:10.1246/cl.1983.913

Reference yield:

: 20335-96-0
(±)-n-butyl(phenyl)phosphine oxide

: 74-88-4
methyl iodide

: 55794-15-5
(S_p)-butylmethylphenylphoshine oxide

: 87219-93-0
(R)-butyl methylphenylphosphine oxide

Guidance literature:: (±)-n-butyl(phenyl)phosphine oxide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere; Glovebox;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h; Overall yield = 80 percent; Overall yield = 59.4 mg; Inert atmosphere; Glovebox;
DOI:10.1002/adsc.202100189

Reference yield:

: 6389-79-3
methyl methylphenylphosphinate

: 87219-93-0
(R)-butyl methylphenylphosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / Inert atmosphere; Schlenk technique

1.2: 20 h / 0 - 60 °C / Inert atmosphere; Schlenk technique

2.1: water / 48 h / 50 °C

3.1: silica gel / ethyl acetate; isopropyl alcohol

With silica gel; magnesium; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;
DOI:10.1002/ejoc.202000035