(2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

Base Information

Chemical Name:(2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine
CAS No.:728944-08-9
Molecular Formula:C₁₇H₂₅NO₂
Molecular Weight:275.391
Hs Code.:

Synonyms:

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Chemical Property of (2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

Chemical Property:

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Technology Process of (2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

There total 13 articles about (2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,6S)-2-Phenylselanylmethyl-6-propyl-piperidine-1-carboxylic acid benzyl ester

: 728944-08-9
(2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

Guidance literature:: With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); In benzene; Heating;
DOI:10.1016/0040-4039(94)02223-X

Reference yield:

: 23632-67-9
(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid

: 728944-08-9
(2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

Guidance literature:: Multi-step reaction with 12 steps

1: BHF-THF

2: CBr₄, PPh₃, KHCO₃ / tetrahydrofuran

3: KOMe / methanol

4: lithium aluminum hydride / diethyl ether

5: NaBH₄ / ethanol

6: KOMe / methanol; tetrahydrofuran

7: 97 percent / N-methylmorpholine / CH₂Cl₂

8: tributylstannane / AlBN / benzene / 6 h / Heating

9: 1.) HSCH₂CH₂SH, BF₃*OEt₂, 2.) Raney-Ni / 1.) DCM, rt; 2.) EtOH

10: 89 percent / zinc iodide / toluene / 4 h / Heating

11: K₂CO₃ / diethyl ether; H₂O / 0 °C

12: tributylstannane / AlBN / benzene / Heating

With 4-methyl-morpholine; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; BHF-THF; boron trifluoride diethyl etherate; potassium methanolate; tri-n-butyl-tin hydride; nickel; potassium carbonate; potassium hydrogencarbonate; ethane-1,2-dithiol; triphenylphosphine; zinc(II) iodide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; benzene;
DOI:10.1016/0040-4039(94)02223-X

Reference yield:

: 115141-89-4
(4S)-3-(benzyloxycarbonyl)-4-(3-hydroxypropyl)-1,3-oxazolidin-5-one

: 728944-08-9
(2R,6S)-1-benzyloxycarbonyl-2-methyl-6-propylpiperidine

Guidance literature:: Multi-step reaction with 11 steps

1: CBr₄, PPh₃, KHCO₃ / tetrahydrofuran

2: KOMe / methanol

3: lithium aluminum hydride / diethyl ether

4: NaBH₄ / ethanol

5: KOMe / methanol; tetrahydrofuran

6: 97 percent / N-methylmorpholine / CH₂Cl₂

7: tributylstannane / AlBN / benzene / 6 h / Heating

8: 1.) HSCH₂CH₂SH, BF₃*OEt₂, 2.) Raney-Ni / 1.) DCM, rt; 2.) EtOH

9: 89 percent / zinc iodide / toluene / 4 h / Heating

10: K₂CO₃ / diethyl ether; H₂O / 0 °C

11: tributylstannane / AlBN / benzene / Heating

With 4-methyl-morpholine; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; boron trifluoride diethyl etherate; potassium methanolate; tri-n-butyl-tin hydride; nickel; potassium carbonate; potassium hydrogencarbonate; ethane-1,2-dithiol; triphenylphosphine; zinc(II) iodide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; benzene;
DOI:10.1016/0040-4039(94)02223-X