FMOC-4-AMINO-3-METHOXYBENZOIC ACID

Base Information

• Chemical Name: FMOC-4-AMINO-3-METHOXYBENZOIC ACID
• CAS No.: 254737-60-5
• Molecular Formula: C₂₃H₁₉NO₅
• Molecular Weight: 389.408
• Mol file: 254737-60-5.mol

Synonyms:

Chemical Property of FMOC-4-AMINO-3-METHOXYBENZOIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Fmoc-4-amino-3-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-4-AMINO-3-METHOXYBENZOIC ACID

There total 1 articles about FMOC-4-AMINO-3-METHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 3-methoxy-4-aminobenzoic acid (2486-69-3) → C23H19NO5 (254737-60-5)

Guidance literature:

In tetrahydrofuran; chloroform; at 60 ℃; for 12h;

DOI:10.3390/ijms22115482

Reference yield:

C23H19NO5 (254737-60-5) → C48H42N6O15S2

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: pyridine / acetone / 8 h / 0 - 20 °C

3.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1 h

4.2: 8 h / 20 °C

With pyridine; thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.3390/ijms22115482

Reference yield:

C23H19NO5 (254737-60-5) → 4-amino-3-methoxy-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: pyridine / acetone / 8 h / 0 - 20 °C

3: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With pyridine; thionyl chloride; diethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.3390/ijms22115482

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

3-methoxy-4-aminobenzoic acid