N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide

Base Information

• Chemical Name: N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide
• CAS No.: 129397-64-4
• Molecular Formula: C₂₆H₃₃N₃O₂
• Molecular Weight: 419.567
• Mol file: 129397-64-4.mol

Synonyms:

Chemical Property of N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide

There total 4 articles about N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

3,3-dimethylbutanoic acid chloride (7065-46-5) + (2-phenylethyl)amine (114779-47-4) → N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide (129397-64-4)

Guidance literature:

With triethylamine; In ethyl acetate; Ambient temperature; overnight;

DOI:10.1016/0223-5234(90)90164-X

Reference yield:

N-(Fmoc)-DL-α-methyltryptophal (114779-80-5) → N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide (129397-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / 1.) ethyl acetate, 30 min, 2.) RT

2: 83 percent / 20percent piperidine / dimethylformamide / 0.5 h / Ambient temperature

3: 23 percent / triethylamine / ethyl acetate / Ambient temperature; overnight

With piperidine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90164-X

Reference yield:

[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3) → N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide (129397-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 20percent piperidine / dimethylformamide / 0.5 h / Ambient temperature

2: 23 percent / triethylamine / ethyl acetate / Ambient temperature; overnight

With piperidine; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90164-X

upstream raw materials:

3,3-dimethylbutanoic acid chloride

(2-phenylethyl)amine

N-(Fmoc)-DL-α-methyltryptophal

[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester