1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

Base Information

Chemical Name:1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one
CAS No.:128218-26-8
Molecular Formula:C₃₉H₄₆Cl₃N₃O₉
Molecular Weight:807.168
Hs Code.:

1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

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Technology Process of 1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

There total 1 articles about 1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 128218-24-6,128218-25-7
4-Amino-2-(6,7-bis-benzyloxy-3-tert-butoxycarbonylamino-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-butyric acid tert-butyl ester

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 128218-13-3
C₃₂H₃₁N₃O₅

: 128218-09-7
5--2,3-dihydro-8,9-bis(benzyloxy)-1H-pyrimido<1,2-a>quinoline-1-carboxylic acid tert-butyl ester

: 128218-26-8,128218-27-9
1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; for 12h;
DOI:10.1021/jo00301a008

Reference yield: 64.0%

: 128218-26-8,128218-27-9
1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

: 128218-28-0,128302-19-2
1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinoline-2-thione

Guidance literature:: With Lawessons reagent; In benzene; Heating; overnight;
DOI:10.1021/jo00301a008

Reference yield:

: 128218-26-8,128218-27-9
1-<1-(tert-Butoxycarbonyl)-3-<(trichloroethoxycarbonyl)amino>propyl>-3-<(tert-butoxycarbonyl)amino>-6,7-bis(benzyloxy)tetrahydroquinolin-2-one

: 128218-09-7
5--2,3-dihydro-8,9-bis(benzyloxy)-1H-pyrimido<1,2-a>quinoline-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / Lawesson's reagent / benzene / Heating; overnight

2: Zn powder, 1 M aq. KH₂PO₄ / tetrahydrofuran / 2 h

3: mercuric acetate / ethanol / 2 h / Heating

With Lawessons reagent; potassium dihydrogenphosphate; mercury(II) diacetate; zinc; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jo00301a008