polyethylene glycol

Base Information

• Chemical Name: polyethylene glycol
• CAS No.: 253222-68-3
• Mol file: 253222-68-3.mol

Synonyms:

Chemical Property of polyethylene glycol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of polyethylene glycol

There total 10 articles about polyethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ polyethylene glycol (253222-68-3,25322-68-3)

Guidance literature:

Reference yield: 90.0%

bromoacetic acid tert-butyl ester (5292-43-3) + poly(ethylene glycol) → polyethylene glycol (253222-68-3,25322-68-3)

Guidance literature:

poly(ethylene glycol); With potassium tert-butylate; In tert-butyl alcohol; benzene; at 35 ℃; for 2h;

bromoacetic acid tert-butyl ester; In tert-butyl alcohol; benzene; at 20 ℃;

With hydrogenchloride; water; more than 3 stages;

Reference yield: 79.0%

mPEG (20 kDa)-amine + N-methoxycarbonylmaleimide (55750-48-6) → polyethylene glycol (253222-68-3,25322-68-3) + mPEG (20 kDa)maleimide + mPEG-maleamic acid

Guidance literature:

mPEG (20 kDa)-amine; In dichloromethane; at 40 ℃;

With sodium carbonate; sodium sulfate; In dichloromethane; at 5 - 5.75 ℃; for 9.5 - 15h;

N-methoxycarbonylmaleimide; In dichloromethane; at 5 - 40 ℃; for 29 - 30.75h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

glycerol

succinic acid anhydride

Z-Lys(Z)-OPfp

N-methoxycarbonylmaleimide

Refernces

• 1、 -. "Catalyst and Method for Production of Polyols by Hydrogenolysis of Carbohydrates". Page/Page column 2-3. . Retrieved 2010/11/29.
• 2、 -. "Conjugates of the hydrophilic polymer and the molecules from boxwood extraction, and pharmaceutical compositions of the conjugates". Page/Page column 4. . Retrieved 2008/06/13.