(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

Base Information

Chemical Name:(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine
CAS No.:142363-26-6
Molecular Formula:C₂₃H₂₉NO₇
Molecular Weight:431.486
Hs Code.:

(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

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Chemical Property of (S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

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Technology Process of (S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

There total 4 articles about (S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21572-32-7
2-chloro-1-phenyl-ethanone oxime

: 142363-22-2
1,2:5,6-di-O-isopropylidene-3-O-(allenyl)-α-D-glucofuranoside

: 142363-26-6
(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

: (R)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

Guidance literature:: With sodium carbonate; In various solvent(s); at 20 ℃; for 144h; Title compound not separated from byproducts;
DOI:10.1055/s-2002-33328

Reference yield:

: 67441-18-3
(3aR,4S,5R,6aR)-5-(2,2-dimethyl-[1,3]dioxolan-4R-yl)-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydrofuro[2,3-d][1,3]dioxole

: 142363-26-6
(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / KOtBu / toluene / 1 h / 110 °C

2: MeOtBu

With tert-butyl methyl ether; potassium tert-butylate; In toluene;

Reference yield:

: 582-52-5
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 142363-26-6
(S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaOH, nBu₄NI / tetrahydrofuran / 96 h / 20 °C

2: 80 percent / KOtBu / toluene / 1 h / 110 °C

3: MeOtBu

With sodium hydroxide; tert-butyl methyl ether; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; toluene;