C₂₄H₂₇N₃O₄

Base Information

Chemical Name:C₂₄H₂₇N₃O₄
CAS No.:1476776-88-1
Molecular Formula:C₂₄H₂₇N₃O₄
Molecular Weight:421.496
Hs Code.:

C<sub>24</sub>H<sub>27</sub>N<sub>3</sub>O<sub>4</sub>

Synonyms:

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Chemical Property of C₂₄H₂₇N₃O₄

Chemical Property:

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Technology Process of C₂₄H₂₇N₃O₄

There total 12 articles about C₂₄H₂₇N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1284448-67-4
isopropyl 4-(4-bromophenyl)-4-oxobutanoate

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

: 1476776-88-1
C₂₄H₂₇N₃O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 1.5 h / 20 - 25 °C / Inert atmosphere

1.2: 2.75 h / 20 - 25 °C / Inert atmosphere

2.1: zinc dibromide / toluene / 2 h / 22 - 30 °C

3.1: pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 47 h / 45 °C / pH 10.5 / Inert atmosphere; Enzymatic reaction

4.1: sodium tetrahydroborate / tetrahydrofuran / 1.33 h / 0 - 2 °C / Inert atmosphere

4.2: 17 h / 5 - 25 °C / Inert atmosphere

5.1: water; Isopropyl acetate / 2.08 h / 40 - 50 °C / Inert atmosphere

6.1: sodium hydroxide / water; tert-butyl methyl ether / 0.08 h / 20 - 25 °C / Inert atmosphere

6.2: 4.5 h / 24 °C / Inert atmosphere

7.1: copper(l) iodide; iron(III) chloride hexahydrate; potassium phosphate; 3,4,7,8-Tetramethyl-o-phenanthrolin / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; iron(III) chloride hexahydrate; pyridoxal 5'-phosphate; potassium tert-butylate; isopropylamine; sodium hydroxide; zinc dibromide; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; water; dimethyl sulfoxide; toluene;
DOI:10.1021/op400233z

Reference yield:

: 1476776-39-2
isopropyl 3-(2-(4-bromophenyl)oxiran-2-yl)-propanoate

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

: 1476776-88-1
C₂₄H₂₇N₃O₄

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc dibromide / toluene / 2 h / 22 - 30 °C

2.1: pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 47 h / 45 °C / pH 10.5 / Inert atmosphere; Enzymatic reaction

3.1: sodium tetrahydroborate / tetrahydrofuran / 1.33 h / 0 - 2 °C / Inert atmosphere

3.2: 17 h / 5 - 25 °C / Inert atmosphere

4.1: water; Isopropyl acetate / 2.08 h / 40 - 50 °C / Inert atmosphere

5.1: sodium hydroxide / water; tert-butyl methyl ether / 0.08 h / 20 - 25 °C / Inert atmosphere

5.2: 4.5 h / 24 °C / Inert atmosphere

6.1: copper(l) iodide; iron(III) chloride hexahydrate; potassium phosphate; 3,4,7,8-Tetramethyl-o-phenanthrolin / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; iron(III) chloride hexahydrate; pyridoxal 5'-phosphate; isopropylamine; sodium hydroxide; zinc dibromide; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; water; dimethyl sulfoxide; toluene;
DOI:10.1021/op400233z

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

: 1476776-88-1
C₂₄H₂₇N₃O₄

Guidance literature:: Multi-step reaction with 9 steps

1.1: aluminum (III) chloride / 85.5 h / 2 - 25 °C / Inert atmosphere

1.2: 1.5 h / 0 - 10 °C / Inert atmosphere

2.1: sulfuric acid / 40 h / 82 - 83 °C / Inert atmosphere

3.1: potassium tert-butylate / dimethyl sulfoxide / 1.5 h / 20 - 25 °C / Inert atmosphere

3.2: 2.75 h / 20 - 25 °C / Inert atmosphere

4.1: zinc dibromide / toluene / 2 h / 22 - 30 °C

5.1: pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 47 h / 45 °C / pH 10.5 / Inert atmosphere; Enzymatic reaction

6.1: sodium tetrahydroborate / tetrahydrofuran / 1.33 h / 0 - 2 °C / Inert atmosphere

6.2: 17 h / 5 - 25 °C / Inert atmosphere

7.1: water; Isopropyl acetate / 2.08 h / 40 - 50 °C / Inert atmosphere

8.1: sodium hydroxide / water; tert-butyl methyl ether / 0.08 h / 20 - 25 °C / Inert atmosphere

8.2: 4.5 h / 24 °C / Inert atmosphere

9.1: copper(l) iodide; iron(III) chloride hexahydrate; potassium phosphate; 3,4,7,8-Tetramethyl-o-phenanthrolin / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; potassium phosphate; copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; iron(III) chloride hexahydrate; sulfuric acid; pyridoxal 5'-phosphate; potassium tert-butylate; isopropylamine; sodium hydroxide; zinc dibromide; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; water; dimethyl sulfoxide; toluene;
DOI:10.1021/op400233z