1038916-08-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylic acid is used as a potential drug candidate for its possible role as an inhibitor or modulator of biological pathways or receptors. The presence of the tert-butoxycarbonyl group suggests its utility as a protective group in organic synthesis, which could be crucial in the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylic acid is used as a protective group for functional groups during chemical reactions. This application is essential for preventing unwanted side reactions and ensuring the selective formation of desired products in complex synthetic sequences.

Upstream product

• 1038916-05-0 tert-butyl (3S)-3-[4-({(1E)-[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate 
• 1171197-20-8 (3S)-3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1196713-67-3 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester 
• 875798-79-1 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 138229-59-1 3-formyl-2-nitrobenzoic acid methyl ester 
• 1196713-21-9 (3S)-3-(4-aminophenyl)piperidine 
• 1312106-32-3 18-(nitrobenzylideneamino)phenylpiperidine-1-carboxylate 
• 4282-46-6 3-(4'-nitrophenyl)pyridine 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 19733-56-3 3-(4-aminophenyl)piperidine 
• 68109-89-7 β-(dimethylamino)-3-carbomethoxy-2-nitrostyrene 
• 1692-25-7 3-pyridylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 132874-06-7 methyl 3-(bromomethyl)-2-nitrobenzoate 

Downstream Products

• 1038916-11-8 tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate 
• 1038915-64-8 (3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride 

Relevant academic research and scientific papers

Derivative based on PARP inhibitor Niraparib and a preparation method and use thereof

The invention discloses a derivative based on a PARP inhibitor Niraparib. The derivative has a structure shown in a formula I as shown in the description, wherein R1 is selected from alkyl, alkoxy, cycloalkyl, aryl alkyl, cycloalkyl alkyl, heterocyclyl, a

Process development of C-N cross-coupling and enantioselective biocatalytic reactions for the asymmetric synthesis of niraparib

Process development of the synthesis of the orally active poly(ADP-ribose)polymerase inhibitor niraparib is described. Two new asymmetric routes are reported, which converge on a high-yielding, regioselective, copper-catalyzed Narylation of an indazole derivative as the late-stage fragment coupling step. Novel transaminase-mediated dynamic kinetic resolutions of racemic aldehyde surrogates provided enantioselective syntheses of the 3-aryl-piperidine coupling partner. Conversion of the C-N cross-coupling product to the final API was achieved by deprotection and salt metathesis to isolate the desired crystalline salt form.

Development of a fit-for-purpose large-scale synthesis of an oral PARP inhibitor

Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discussed,

PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE

The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl)transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA -damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.