(S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: (S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE
• CAS No.: 1260220-67-4
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 1260220-67-4.mol

Synonyms:

Chemical Property of (S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

Chemical Property:

Purity/Quality:

99.00% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

There total 3 articles about (S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyl pyrrolidine-1-carboxylate (86953-79-9) + 4-bromo-aniline (106-40-1) → (R)-tert-butyl 2-(4-aminophenyl)pyrrolidine-1-carboxylate (889947-54-0,1260220-67-4)

Guidance literature:

tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 0.0833333h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; at -30 - 20 ℃; for 1h; Inert atmosphere;

4-bromo-aniline; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; diethyl ether; hexane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol1017799

Reference yield:

tert-butyl pyrrolidine-1-carboxylate (86953-79-9) + 4-bromo-aniline (106-40-1) → (+)-N-(tert-butoxycarbonyl)-2-(4-aminophenyl)pyrrolidine (1260220-67-4) + (-)-N-(tert-butoxycarbonyl)-2-(4-aminophenyl)pyrrolidine (1260220-67-4)

Guidance literature:

tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (-)-sparteine; In cyclohexane; at -78 - -68 ℃; for 3h;

With zinc(II) chloride; In diethyl ether; cyclohexane; at -74 - 20 ℃;

4-bromo-aniline; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In diethyl ether; cyclohexane; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/ja0605265

Reference yield:

tert-butyl pyrrolidine-1-carboxylate (86953-79-9) + 4-bromo-aniline (106-40-1) → (+)-N-(tert-butoxycarbonyl)-2-(4-aminophenyl)pyrrolidine (1260220-67-4) + (-)-N-(tert-butoxycarbonyl)-2-(4-aminophenyl)pyrrolidine (1260220-67-4)

Guidance literature:

tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (-)-sparteine; In cyclohexane; at -78 - -68 ℃; for 3h;

With zinc(II) chloride; In diethyl ether; cyclohexane; at -74 - 20 ℃;

4-bromo-aniline; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In diethyl ether; cyclohexane; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/ja0605265

upstream raw materials:

tert-butyl pyrrolidine-1-carboxylate

4-bromo-aniline

Refernces

• 1、 -. "TANK-BINDING KINASE INHIBITOR COMPOUNDS". Paragraph 1936. . Retrieved 2016/05/02.