GNF 4877

Base Information

Chemical Name:GNF 4877
CAS No.:2041073-22-5
Molecular Formula:C₂₅H₂₇FN₆O₄
Molecular Weight:494.526
Hs Code.:

Synonyms:

Suppliers and Price of GNF 4877

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
CID139600315(GNF-4877)
001
$ 400.00

ChemScene
GNF4877 98.85%
5mg
$ 700.00

ChemScene
GNF4877 98.85%
50mg
$ 3570.00

ChemScene
GNF4877 98.85%
25mg
$ 2100.00

ChemScene
GNF4877 98.85%
10mg
$ 1100.00

Ambeed
(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylicacid 98%
100mg
$ 1071.00

Ambeed
(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylicacid 98%
50mg
$ 599.00

Ambeed
(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylicacid 98%
25mg
$ 339.00

Total 9 raw suppliers

Chemical Property of GNF 4877

Chemical Property:

Boiling Point:669.7±55.0 °C(Predicted)
Density:1.367±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

CID139600315(GNF-4877) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of GNF 4877

There total 6 articles about GNF 4877 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: ethyl (R)-1-(3-(3-amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylate

: 2041073-22-5
GNF 4877

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 4h;
DOI:10.1002/cmdc.202000183

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 2041073-22-5
GNF 4877

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 4.5 h / 0 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 25 °C / 2585.81 Torr

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 18 h / 25 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 4 h / 25 °C

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.202000183

Reference yield:

: 486424-37-7
3-amino-6-bromo-pyrazine-2-carboxylic acid

: 2041073-22-5
GNF 4877

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 3 h / 90 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 18 h / 25 °C

3: lithium hydroxide; water / methanol; tetrahydrofuran / 4 h / 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1002/cmdc.202000183