3-azaspiro[5.5]undecane hydrochloride

Base Information

• Chemical Name: 3-azaspiro[5.5]undecane hydrochloride
• CAS No.: 1125-01-5
• Molecular Formula: C10H19 N . Cl H
• Molecular Weight: 189.728
• Hs Code.: 2933990090
• Mol file: 1125-01-5.mol

Synonyms:3-Azaspiro[5.5]undecane,hydrochloride (7CI,8CI,9CI)

Chemical Property of 3-azaspiro[5.5]undecane hydrochloride

Chemical Property:

• Vapor Pressure: 0.00437mmHg at 25°C
• Boiling Point: 273.7°C at 760 mmHg
• Flash Point: 119.3°C
• PSA: 12.03000
• LogP: 3.45110
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4-Pentamethylenepiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2). 4,4-Pentamethylenepiperidine Hydrochloride is a M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2).

Technology Process of 3-azaspiro[5.5]undecane hydrochloride

There total 2 articles about 3-azaspiro[5.5]undecane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-azaspiro[5.5]undecane (180-44-9) → 3-azaspiro[5.5]undecane hydrochloride (1125-01-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃;

Reference yield: 75.0%

3-azaspiro[5.5]undecane-2,4-dione (1130-32-1) → 3-azaspiro[5.5]undecane hydrochloride (1125-01-5)

Guidance literature:

3-azaspiro[5.5]undecane-2,4-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; Reflux;

With hydrogenchloride; In diethyl ether;

Reference yield: 78.0%

3-azaspiro[5.5]undecane hydrochloride (1125-01-5) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 3-((4-nitrophenyl)sulfonyl)-3-azaspiro[5.5]undecane

Guidance literature:

With pyridine; In tetrahydrofuran; at 60 ℃; for 0.333333h;

DOI:10.1021/ml5003234

upstream raw materials:

3-azaspiro[5.5]undecane

3-azaspiro[5.5]undecane-2,4-dione

Refernces

• 1、 Wang, Jun,Cady, Sarah D.,Balannik, Victoria,Pinto, Lawrence H.,DeGrado, William F.,Hong, Mei. "Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus". experimental part. p. 8066 - 8076. Retrieved 2009/12/03.