2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide

Base Information

Chemical Name:2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide
CAS No.:105875-34-1
Molecular Formula:C16H16BrNO3
Molecular Weight:350.212
Hs Code.:
DSSTox Substance ID:DTXSID001245104
Nikkaji Number:J2.422.803G

Synonyms:DTXSID001245104;105875-34-1;2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide

Suppliers and Price of 2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:349.03136
Heavy Atom Count:21
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)C(=O)NCC2=CC=CC=C2)Br)OC

Technology Process of 2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide

There total 2 articles about 2-Bromo-4,5-dimethoxy-N-(phenylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55171-61-4
2-bromo-4,5-dimethoxybenzoyl chloride

: 100-46-9
benzylamine

: 105875-34-1
N-benzyl-2-bromo-4,5-dimethoxybenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol062599z

Reference yield:

: 6286-46-0
2-bromo-4,5-dimethoxybenzoic acid

: 105875-34-1
N-benzyl-2-bromo-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene; dimethylformamide / 0 - 70 °C

2: 305 mg / triethylamine / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol062599z

Reference yield: 92.0%

: 105875-34-1
N-benzyl-2-bromo-4,5-dimethoxybenzamide

: 146776-45-6
5-(phenylmethyl)-2,3,8,9-tetramethoxy-6(5H)-phenanthridinone

Guidance literature:: With [2-(8-methoxynaphthalen-1-yl)phenyl]diphenylphosphane; caesium carbonate; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 24h;
DOI:10.1021/ol062599z