(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

Base Information

Chemical Name:(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide
CAS No.:1159488-95-5
Molecular Formula:C₂₄H₂₂BrF₅N₄O
Molecular Weight:557.361
Hs Code.:

(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

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Technology Process of (S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

There total 2 articles about (S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 847358-98-9
N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]-4-fluoro-L-leucine

: 1159489-36-7
4-[(2S)-(2-amino-2-cyanoethyl)]-3-fluorobenzonitrile

: 1159488-95-5
(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

Guidance literature:: With 2,6-dimethylpyridine; HATU; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/j.bmcl.2010.10.015

Reference yield:

: 1159488-95-5
(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

Guidance literature:

Reference yield:

: 1159488-95-5
(S)-2-[(S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [(S)-1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1159488-48-8
Cz₀₀₇

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/j.bmcl.2010.10.015