cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one

Base Information

• Chemical Name: cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one
• CAS No.: 131791-76-9
• Molecular Formula: C₉H₁₅N₂O₃*K
• Molecular Weight: 238.328
• Mol file: 131791-76-9.mol

Synonyms:

Chemical Property of cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one

There total 2 articles about cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-asparagine (70-47-3,28088-48-4,7006-34-0) + pivalaldehyde (630-19-3) → cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one (131791-76-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1016/S0957-4166(00)80511-X

Reference yield:

L-asparagine (70-47-3,28088-48-4,7006-34-0) + pivalaldehyde (630-19-3) → cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one (131791-76-9) + Potassium; (2S,4S)-2-tert-butyl-6-oxo-hexahydro-pyrimidine-4-carboxylate

Guidance literature:

With potassium hydroxide; Multistep reaction. Title compound not separated from byproducts; 1.) MeOH, reflux, 1.5 h, 2.) MeOH, reflux 8 h;

DOI:10.1016/0957-4166(96)00278-9

Reference yield: 100.0%

benzoyl chloride (98-88-4) + cis-2-tert-butyl-6(S)-potassium carboxylate-perhydropyrimidin-4-one (131791-76-9) → 1-benzoyl-2(S)-tert-butyl-6(S)-carboxy-perhydropyrimidin-4-one (143870-65-9)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1016/S0957-4166(00)80511-X

upstream raw materials:

L-asparagine

pivalaldehyde

Downstream raw materials:

1-benzoyl-2(S)-tert-butyl-6(S)-carboxy-perhydropyrimidin-4-one

(2S,6S)-2-tert-butyl-1-carbobenzoxy-6-carboxy-4-pyrimidone

1-benzoyl-2(S)-tert-butyl-2,3-dihydro-4(1H)-pyrimidin-4-one

1-benzoyl-2(S)-tert-butyl-3-methyl-2,3-dihydro-4(1H)-pyrimidin-4-one