Technology Process of C21H35N3O5
There total 4 articles about C21H35N3O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
1.2: 0 - 20 °C
2.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
2.2: pH 1
3.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
3.2: 12 h / Inert atmosphere
4.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
4.2: pH 1
5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / Inert atmosphere
With
1-hydroxy-7-aza-benzotriazole; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2010.10.037
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium hydroxide / ethanol / 0 °C
1.2: pH 1
2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C
2.2: 1.5 h / -15 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 13 h / 0 - 20 °C
4.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
4.2: 0 - 20 °C
5.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
5.2: pH 1
6.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
6.2: 12 h / Inert atmosphere
7.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
7.2: pH 1
8.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / Inert atmosphere
With
1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
3.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2010.10.037
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C
1.2: 1.5 h / -15 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 13 h / 0 - 20 °C
3.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
3.2: 0 - 20 °C
4.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
4.2: pH 1
5.1: hydrazine hydrate / methanol / 0.67 h / 20 °C
5.2: 12 h / Inert atmosphere
6.1: sodium hydroxide / ethanol; water / 20 h / 20 °C
6.2: pH 1
7.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / Inert atmosphere
With
1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
2.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2010.10.037
