C₂₅H₃₁F⁽¹⁸⁾FNO₄

Base Information

Chemical Name:C₂₅H₃₁F⁽¹⁸⁾FNO₄
CAS No.:1402843-08-6
Molecular Formula:C₂₅H₃₁F₂NO₄
Molecular Weight:446.524
Hs Code.:

C<sub>25</sub>H<sub>31</sub>F<sup>(18)</sup>FNO<sub>4</sub>

Synonyms:

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Chemical Property of C₂₅H₃₁F⁽¹⁸⁾FNO₄

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Technology Process of C₂₅H₃₁F⁽¹⁸⁾FNO₄

There total 6 articles about C₂₅H₃₁F⁽¹⁸⁾FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402843-07-5
(2-methoxy-3-(tosyloxyethyloxy)phenyl)-(1-(2-p-fluorophenylethyl)-piperidine-4-yl)-methyl acetate

: 1402843-08-6
C₂₅H₃₁F⁽¹⁸⁾FNO₄

Guidance literature:: With Kryptofix₂₂₂; potassium carbonate; In water; acetonitrile; at 80 ℃; for 0.416667h; Inert atmosphere;
DOI:10.1002/jlcr.2947

Reference yield:

: 332-42-3
(2-bromoethyl)-4-fluorobenzene

: 1402843-08-6
C₂₅H₃₁F⁽¹⁸⁾FNO₄

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 85 °C

2: tetrahydrofuran / 18 h / 20 °C

3: ammonium fluoride / methanol / 0.5 h / Reflux

4: caesium carbonate / acetonitrile / 16 h / Reflux

5: Kryptofix₂₂₂; potassium carbonate / acetonitrile; water / 0.42 h / 80 °C / Inert atmosphere

With ammonium fluoride; Kryptofix₂₂₂; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; sodium iodide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: |Williamson Ether Synthesis;
DOI:10.1002/jlcr.2947

Reference yield:

: 252364-42-4
(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

: 1402843-08-6
C₂₅H₃₁F⁽¹⁸⁾FNO₄

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 18 h / 20 °C

2: ammonium fluoride / methanol / 0.5 h / Reflux

3: caesium carbonate / acetonitrile / 16 h / Reflux

4: Kryptofix₂₂₂; potassium carbonate / acetonitrile; water / 0.42 h / 80 °C / Inert atmosphere

With ammonium fluoride; Kryptofix₂₂₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; water; acetonitrile; 3: |Williamson Ether Synthesis;
DOI:10.1002/jlcr.2947