propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Base Information

• Chemical Name: propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate
• CAS No.: 1268385-13-2
• Molecular Formula: C₂₉H₂₂F₅N₅O₃
• Molecular Weight: 583.517
• Mol file: 1268385-13-2.mol

Synonyms:

Chemical Property of propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

There total 15 articles about propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate (1268385-13-2)

Guidance literature:

Reference yield: 71.0%

propan-1-ol (71-23-8) + methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate (1268385-07-4) → propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate (1268385-13-2)

Guidance literature:

With triethylamine; at 22 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo4014595

Reference yield:

2-(2,3-difluorophenyl)-1H-imidazole (1268385-42-7) → propyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate (1268385-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / water / 0.17 h / 25 °C / Inert atmosphere; Large scale

1.2: 10 h / 25 - 50 °C / Inert atmosphere; Large scale

2.1: Pt(5%)Bi(5%)/C; sodium hydroxide / water; acetonitrile / 5 h / 23 - 45 °C

3.1: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / 3 h / 22 °C / Inert atmosphere

With Pt(5%)Bi(5%)/C; hydrogen bromide; triethylamine; potassium hydroxide; sodium hydroxide; In water; acetic acid; ethyl acetate; acetonitrile;

DOI:10.1021/jo4014595

upstream raw materials:

2,3-difluorobenzaldehyde

2-(2,3-difluorophenyl)-1H-imidazole

(2-(2,3-difluorophenyl)-1H-imidazole-4,5-diyl)dimethanol

2-(2,3-difluorophenyl)-1H-imidazole-4,5-dicarbaldehyde