methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Base Information

Chemical Name:methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate
CAS No.:1268385-07-4
Molecular Formula:C₂₇H₁₈F₅N₅O₃
Molecular Weight:555.464
Hs Code.:

Synonyms:methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

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Chemical Property of methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

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Technology Process of methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

There total 12 articles about methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1268385-46-1
2-(2,3-difluorophenyl)-1H-imidazole-4,5-dicarbaldehyde

: 1268385-51-8
bis(1,1-dimethylethyl) 1-[1-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-2-(methyloxy)-2-oxoethyl]-1,2-hydrazinedicarboxylate

: 1268385-07-4
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: With hydrogen bromide; In acetic acid; ethyl acetate; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo4014595

Reference yield:

: 2646-91-5
2,3-difluorobenzaldehyde

: 1268385-07-4
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / water; isopropyl alcohol / 6 h / 25 °C / Inert atmosphere; Large scale

2.1: potassium hydroxide / water / 0.17 h / 25 °C / Inert atmosphere; Large scale

2.2: 10 h / 25 - 50 °C / Inert atmosphere; Large scale

3.1: Pt(5%)Bi(5%)/C; sodium hydroxide / water; acetonitrile / 5 h / 23 - 45 °C

4.1: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C / Inert atmosphere

With Pt(5%)Bi(5%)/C; ammonium acetate; hydrogen bromide; potassium hydroxide; sodium hydroxide; In water; acetic acid; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo4014595

Reference yield:

: 1268385-44-9
(2-(2,3-difluorophenyl)-1H-imidazole-4,5-diyl)dimethanol

: 1268385-07-4
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / methanol / 2 h / 25 - 45 °C / Inert atmosphere

2: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C / Inert atmosphere

With manganese(IV) oxide; hydrogen bromide; In methanol; acetic acid; ethyl acetate;
DOI:10.1021/jo4014595