2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

Base Information

• Chemical Name: 2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine
• CAS No.: 105925-39-1
• Molecular Formula: C20H14ClNO2S
• Molecular Weight: 367.856
• European Community (EC) Number: 855-169-0
• ChEMBL ID: CHEMBL1801816

Synonyms:Tubulin inhibitor 6;105925-39-1;iHAP1;2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine;(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone;CHEMBL1801816;(2-chlorophenothiazin-10-yl)-(4-methoxyphenyl)methanone;Oprea1_789892;SCHEMBL22147462;CUN25391;EX-A4126;BDBM50483987;s9695;AKOS001020463;BS-46458;HY-136121;CS-0119638;E75426;EN300-6486380;Z56843374

Chemical Property of 2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 367.0433776
• Heavy Atom Count: 25
• Complexity: 482

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl

Technology Process of 2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

There total 2 articles about 2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chlorophenothiazine (92-39-7) + 4-methoxy-benzoyl chloride (100-07-2) → 2-chloro-10H-phenothiazin-10-yl-(4-methoxyphenyl)-methanone (105925-39-1)

Guidance literature:

In toluene; at 110 ℃;

DOI:10.1039/c5md00274e

Reference yield:

→ 2-chloro-10H-phenothiazin-10-yl-(4-methoxyphenyl)-methanone (105925-39-1)

Guidance literature:

aus Phenothiazin, d. Benzoylchlorid;

Reference yield: 62.0%

2-chloro-10H-phenothiazin-10-yl-(4-methoxyphenyl)-methanone (105925-39-1) → 2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine-5-oxide (1309924-88-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm200436t

upstream raw materials:

2-chlorophenothiazine

4-methoxy-benzoyl chloride

Downstream raw materials:

2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine-5-oxide

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