2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl

Base Information

• Chemical Name: 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl
• CAS No.: 1373123-16-0
• Molecular Formula: C₂₂H₂₄O₂
• Molecular Weight: 320.431
• Mol file: 1373123-16-0.mol

Synonyms:

Chemical Property of 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl

There total 2 articles about 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

2-(2-hydroxyadamantan-2-yl)-3'-methoxybiphenyl (1373123-31-9) → 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl (1373123-16-0)

Guidance literature:

With sodium ethanolate; sodium hydride; ethanethiol; In ethanol; N,N-dimethyl-formamide; for 4h; Inert atmosphere; Reflux;

DOI:10.1039/c1pp05338h

Reference yield:

2-Adamantanone (700-58-3) → 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl (1373123-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 20 °C / Inert atmosphere; Reflux

1.3: Inert atmosphere

2.1: sodium ethanolate; sodium hydride; ethanethiol / ethanol; N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

With iodine; sodium ethanolate; sodium hydride; magnesium; ethanethiol; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1.2: Grignard reaction / 1.3: Grignard reaction;

DOI:10.1039/c1pp05338h

Reference yield: 43.0%

methanol (67-56-1) + 2-(2-hydroxyadamantan-2-yl)-3'-hydroxybiphenyl (1373123-16-0) → spiro[adamantane-2,9'-fluorene]-1'-ol (1373123-21-7) + spiro[adamantane-2,9'-fluorene]-3'-ol (1373123-22-8) + 2-(2-methoxyadamantan-2-yl)-3'-hydroxybiphenyl (1373123-32-0)

Guidance literature:

With water; for 0.5h; Inert atmosphere; Irradiation; Solvolysis;

DOI:10.1039/c1pp05338h

upstream raw materials:

2-Adamantanone

2-(2-hydroxyadamantan-2-yl)-3'-methoxybiphenyl

Downstream raw materials:

spiro[adamantane-2,9'-fluorene]-1'-ol

spiro[adamantane-2,9'-fluorene]-3'-ol

2-(2-methoxyadamantan-2-yl)-3'-hydroxybiphenyl