2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one

Base Information

Chemical Name:2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one
CAS No.:58536-95-1
Molecular Formula:C₁₆H₁₅FN₄O
Molecular Weight:298.32
Hs Code.:
European Community (EC) Number:664-865-1
Wikidata:Q107140094

Synonyms:2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one;58536-95-1;SCHEMBL11819379;DFYCWKAPROXTHP-UHFFFAOYSA-N;AKOS024336101;1-(4'-fluorobenzyl)-2-dimethylamino-pyrido[2,3-d]pyrimidin-4(1H)-one

Suppliers and Price of 2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:298.12298928
Heavy Atom Count:22
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C1=NC(=O)C2=C(N1CC3=CC=C(C=C3)F)N=CC=C2

Technology Process of 2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one

There total 9 articles about 2-(Dimethylamino)-1-(4-fluorobenzyl)pyrido[2,3-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58536-94-0
1-<(4-fluorophenyl)methyl>-2-methylaminopyrido<2,3-d>pyrimidin-4(1H)-one

: 74-88-4
methyl iodide

: 58536-95-1
2-dimethylamino-1-<(4-fluorophenyl)methyl>pyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: In tetrahydrofuran; dichloromethane; chloroform;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 58536-95-1
2-dimethylamino-1-<(4-fluorophenyl)methyl>pyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) potassium carbonate, 2) Cu / 1) water, RT, 2) dimethylformamide, reflux, 8 h

2: 62 percent / sodium carbonate / H₂O; benzene / 18 h / Ambient temperature

3: 18 percent / NaOH / dioxane / 6 h / Heating

4: 1) potassium t-butoxide / 1) THF, RT, 45 min, 2) 24 h

With potassium tert-butylate; copper; sodium carbonate; potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; benzene;

Reference yield:

: 97484-91-8
2-<(4-fluorophenyl)methylamino>-3-pyridinecarboxylic acid

: 58536-95-1
2-dimethylamino-1-<(4-fluorophenyl)methyl>pyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / sodium carbonate / H₂O; benzene / 18 h / Ambient temperature

2: 18 percent / NaOH / dioxane / 6 h / Heating

3: 1) potassium t-butoxide / 1) THF, RT, 45 min, 2) 24 h

With potassium tert-butylate; sodium carbonate; sodium hydroxide; In 1,4-dioxane; water; benzene;