Technology Process of 6-(5-acetoxy-2-methoxybenzoyl)-5,8-dimethoxy-2,2-dimethylchromene
There total 10 articles about 6-(5-acetoxy-2-methoxybenzoyl)-5,8-dimethoxy-2,2-dimethylchromene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
for 5h;
Inert atmosphere;
Reflux;
DOI:10.1021/jo200303c
- Guidance literature:
-
Multi-step reaction with 8 steps
1: water; hydrogen bromide; acetic acid / 36 h / Reflux
2: potassium carbonate / methanol / 120 h / 20 - 60 °C / Inert atmosphere
3: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere
4: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere
5: toluene / 22 h / Inert atmosphere; Reflux
6: methanol; N,N-dimethyl-formamide / 80 °C / Inert atmosphere
7: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 1.5 h / 20 °C / Inert atmosphere
8: pyridine / 5 h / Inert atmosphere; Reflux
With
pyridine; cyclohexa-1,4-diene; palladium 10% on activated carbon; water; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
5: Claisen cyclization;
DOI:10.1021/jo200303c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere
2: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere
3: toluene / 22 h / Inert atmosphere; Reflux
4: methanol; N,N-dimethyl-formamide / 80 °C / Inert atmosphere
5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 1.5 h / 20 °C / Inert atmosphere
6: pyridine / 5 h / Inert atmosphere; Reflux
With
pyridine; cyclohexa-1,4-diene; palladium 10% on activated carbon; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
3: Claisen cyclization;
DOI:10.1021/jo200303c
