5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

Base Information

Chemical Name:5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone
CAS No.:1296257-40-3
Molecular Formula:C₂₆H₂₂F₂O₄
Molecular Weight:436.455
Hs Code.:

Synonyms:5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

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Chemical Property of 5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

Chemical Property:

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Technology Process of 5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

There total 6 articles about 5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 1296257-39-0
5'-benzyloxy-2,2'-difluoro-4-hydroxy-5-methoxybenzophenone

: 1296257-40-3
5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo200303c

Reference yield:

: 1296257-38-9
5'-benzyloxy-2,2'-difluoro-5-methoxy-4-nitrobenzophenone

: 1296257-40-3
5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride; In dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/jo200303c

Reference yield:

: 1015414-82-0
(2,5-difluoro-4-nitrophenyl)(2-fluoro-5-methoxyphenyl)methanone

: 1296257-40-3
5-benzyloxy-2,2'-difluoro-4-(1,1-dimethylpropargyloxy)-5'-methoxybenzophenone

Guidance literature:: Multi-step reaction with 4 steps

1: water; hydrogen bromide; acetic acid / 36 h / Reflux

2: potassium carbonate / methanol / 120 h / 20 - 60 °C / Inert atmosphere

3: sodium hydride; Benzaldoxime / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With water; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; Benzaldoxime; copper dichloride; In methanol; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/jo200303c