C₂₄H₂₂F₃NO₄

Base Information

Chemical Name:C₂₄H₂₂F₃NO₄
CAS No.:1373038-08-4
Molecular Formula:C₂₄H₂₂F₃NO₄
Molecular Weight:445.438
Hs Code.:

C<sub>24</sub>H<sub>22</sub>F<sub>3</sub>NO<sub>4</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₄H₂₂F₃NO₄

Chemical Property:

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Technology Process of C₂₄H₂₂F₃NO₄

There total 12 articles about C₂₄H₂₂F₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2314-97-8,263005-66-9
iodotrifluoromethane

: 1373037-80-9
(S)-3-(3-(benzofuran-2-yl)propanoyl)-4-benzyl-5,5-dimethyloxazolidin-2-one

: 1373038-08-4
C₂₄H₂₂F₃NO₄

: 1373038-18-6
C₂₄H₂₂F₃NO₄

Guidance literature:: (S)-3-(3-(benzofuran-2-yl)propanoyl)-4-benzyl-5,5-dimethyloxazolidin-2-one; With tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine; In dichloromethane; at -78 - 24 ℃; for 0.0833333h; Inert atmosphere;

iodotrifluoromethane; In dichloromethane; at -78 - 45 ℃; for 17h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja302552e

Reference yield:

: 1207362-36-4
(S)-4-benzyl-3-hexanoyl-5,5-dimethyloxazolidin-2-one

: 1373038-08-4
C₂₄H₂₂F₃NO₄

: 1373038-18-6
C₂₄H₂₂F₃NO₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / 22 - 24 °C / Inert atmosphere

1.2: 5 h / 24 - 45 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 5 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2.5 h / -78 - 0 °C / Inert atmosphere

4.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere

4.2: 17 h / -78 - 45 °C / Inert atmosphere

With tris(triphenylphosphine)ruthenium(II) chloride; n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ja302552e

Reference yield:

: 1373037-72-9
(S)-4-benzyl-3-(2-cyclohexylacetyl)-5,5-dimethyloxazolidin-2-one

: 1373038-08-4
C₂₄H₂₂F₃NO₄

: 1373038-18-6
C₂₄H₂₂F₃NO₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere

1.2: 17 h / -78 - 45 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2.5 h / -78 - 0 °C / Inert atmosphere

4.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium(IV) chloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere

4.2: 17 h / -78 - 45 °C / Inert atmosphere

With tris(triphenylphosphine)ruthenium(II) chloride; n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ja302552e