diethyl 2,3-dibenzylsuccinate

Base Information

• Chemical Name: diethyl 2,3-dibenzylsuccinate
• CAS No.: 79909-17-4
• Molecular Formula: C₂₂H₂₆O₄
• Molecular Weight: 354.446
• Mol file: 79909-17-4.mol

Synonyms:

Chemical Property of diethyl 2,3-dibenzylsuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 2,3-dibenzylsuccinate

There total 7 articles about diethyl 2,3-dibenzylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + Ethyl 2-phenylethanoate (101-97-3) → (2RS,3RS)-diethyl 2,3-dibenzylbutanedioate (79909-17-4,125304-99-6,125305-00-2) + (2R,3S)-diethyl 2,3-dibenzylbutanedioate (125304-99-6) + ethyl 2-(2,2,6,6-tetramethylpiperidin-1-yloxy)phenylacetate

Guidance literature:

Ethyl 2-phenylethanoate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; With ferrocenium hexafluorophosphate; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201200736

Reference yield: 84.0%

benzyl bromide (100-39-0) + succinic acid diethyl ester (123-25-1) → diethyl 2,3-dibenzylsuccinate (79909-17-4)

Guidance literature:

With lithium diisopropyl amide; 1.) THF, -78 deg C, 2.) HMPA, -78 deg C -> room temperature;

DOI:10.1246/cl.1982.687

Reference yield: 80.0%

lithium di-enolate of diethyl succinate → diethyl 2,3-dibenzylsuccinate (79909-17-4)

Guidance literature:

In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

upstream raw materials:

ethanol

racem.-2,3-dibenzyl-succinic acid

benzyl bromide

succinic acid diethyl ester

Downstream raw materials:

2,3-dibenzyl-1,4-diol