88010-86-0

Upstream product

• 826-41-5 N-Methyl-2,2-diethoxypyrrolidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 958-09-8 2'-deoxy-D-adenosine 
• 17331-12-3 N⁶-(dimethylamino-methylene)-2'-deoxy-adenosine 
• 39650-82-3 2,2-dimethoxy-1-methylpyrrolidine 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 88010-85-9 6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine 

Downstream Products

• 88010-87-1 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester 
• 172033-41-9 {9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[1-methyl-pyrrolidin-(2Z)-ylidene]-amine 
• 134817-00-8 Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester 

Relevant academic research and scientific papers

Amidine Protecting Groups for Oligonucleotide Synthesis

Amidines have been investigated for protection of deoxyadenosine, deoxycytidine, 5-methyldeoxycytidine, cytidine, and deoxyguanosine.These amidine-protected nucleosides and their 5'-bis(p-anisylphenyl)methyl derivatives were prepared in high yield (79-100

N6(N-METHYL-2-PYRROLIDINE AMIDINE)DEOXYADENOSINE - A NEW DEOXYNUCLEOSINE PROTECTING GROUP

The synthesis and characterization of N6(N-methyl-2-pyrrolidine amidine) 2'-deoxyadenosine is described.This amidine is significantly more stable toward acid catalyzed depurination than N-benzoyldeoxyadenosine, is easy to prepare and can be removed rapidly and quantitatively.