ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate

Base Information

• Chemical Name: ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate
• CAS No.: 1497435-99-0
• Molecular Formula: C₁₉H₁₉ClN₄O₃S
• Molecular Weight: 418.904
• Mol file: 1497435-99-0.mol

Synonyms:

Chemical Property of ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate

There total 3 articles about ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate (1202357-66-1) + p-Methoxybenzyl bromide (2746-25-0) → ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate (1497435-99-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 18h; Cooling with ice;

DOI:10.1248/cpb.c13-00248

Reference yield:

2-amino-thiazole-5-carboxylic acid ethyl ester (32955-21-8) → ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate (1497435-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 25 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C / Cooling with ice

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.c13-00248

Reference yield:

2,4-dichloro-2-methylpyrimidine (1780-26-3) → ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate (1497435-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 25 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C / Cooling with ice

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.c13-00248

upstream raw materials:

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate

p-Methoxybenzyl bromide

2-amino-thiazole-5-carboxylic acid ethyl ester

2,4-dichloro-2-methylpyrimidine

Downstream raw materials:

(2E)-N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxamide

(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

C₃₀H₃₀⁽²⁾H₄ClN₇O₃S

C₄₁H₄₉⁽²⁾H₄ClN₈O₆S