(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

Base Information

Chemical Name:(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide
CAS No.:1497436-11-9
Molecular Formula:C₂₈H₃₀ClN₇O₂S
Molecular Weight:564.111
Hs Code.:

(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

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Chemical Property of (2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

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Technology Process of (2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

There total 5 articles about (2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1497435-99-0
ethyl (2E)-2-[(6-chloro-2-methylpyrimidin-4-yl)imino]-3-(4-methoxybenzyl)-2,3-dihydro-1,3-thiazole-5-carboxylate

: 1497436-11-9
(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / tetrahydrofuran; methanol / 18 h / 5 - 25 °C

2: thionyl chloride / tetrahydrofuran / 5 h / 45 °C

3: tetrahydrofuran / 18 h / 45 °C

4: 1,4-dioxane / 24 h / Reflux

With thionyl chloride; water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1248/cpb.c13-00248

Reference yield:

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 1497436-11-9
(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 25 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C / Cooling with ice

3: water; sodium hydroxide / tetrahydrofuran; methanol / 18 h / 5 - 25 °C

4: thionyl chloride / tetrahydrofuran / 5 h / 45 °C

5: tetrahydrofuran / 18 h / 45 °C

6: 1,4-dioxane / 24 h / Reflux

With thionyl chloride; water; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00248

Reference yield:

: 1202357-66-1
ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate

: 1497436-11-9
(2E)-N-(2-chloro-6-methylphenyl)-3-(4-methoxybenzyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)imino]-2,3-dihydro-1,3-thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C / Cooling with ice

2: water; sodium hydroxide / tetrahydrofuran; methanol / 18 h / 5 - 25 °C

3: thionyl chloride / tetrahydrofuran / 5 h / 45 °C

4: tetrahydrofuran / 18 h / 45 °C

5: 1,4-dioxane / 24 h / Reflux

With thionyl chloride; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00248